Review on Camptothecin Producing Medicinal Plant: Nothapodytes Nimmoniana

Vanshika Shrivastava^1*, Naveen Sharma² , Vikas Shrivastava¹ and Ajay Sharma³

¹Amity Institute of Biotechnology, Amity University Madhya Pradesh Gwalior, India-474005

²Amity Institute of Pharmacy, Amity University Madhya Pradesh Gwalior, India-474005

³Department. of Pharmacognocy, Delhi Pharmaceutical sciences and Research University, New Delhi-110017

Corresponding Author E-mail: naveenpcol@gmail.com

Abstract: Nothapodytes nimmoniana is an endangered medicinal plant widely distributed throughout the Western Ghats of India. The plant contains camptothecin (CPT) which is renowned anticancer drugs. Though, CPT found in many plant species but maximum amount of CPT has been reported from N. nimmoniana. Due to very good source of CPT, this plant has been explored for its Phytochemical, Biotechnological and Pharmacological aspects. Looking to the huge global demand for CPT, overexploitation of N. nimmoniana, unplanned deforestation, and lowest production of CPT from intact plant, reduction of seed germination, high market cost and not have economically feasible process of production has optimistic us to investigate this plant in a systematic manner. The proposed article can be utilized for the establishment of extraction methods and analytical protocol for CPT. Also, Bioreactors production of CPT using high yielding cell line of N. nimmoniana. The pharmacological data will be applicable for discovery of new Drug and development lead to novel compounds which are safe and effective.

Keywords: Anticancer; Camptothecin; Biotechnological; Nothapodytes Nimmoniana; Medicinal plant; Pharmacological

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