Protective Effect of Tylophora Indica Against Streptozotocin Induced Pancreatic and Liver Dysfunction in Wistar Rats
Swathi Putta1*, Kotaiah Silakabattini1 and Jagadeesh Kumar T21A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India
2Santhi Healthcare India Pvt Ltd., Medchal, Hyderabad, Telangana, India
Corresponding Author E-mail: swathidbmp@gmail.com
Abstract: The objective of the study is to evaluate the ethanolic leaf extract of Tylophora indica (ELTI) on pancreatic and hepatic oxidative stress in streptozotocin (STZ) induced diabetic rats. The serum blood glucose and liver enzymes (AST, ALT and ALP) were estimated in all the groups. The elevated blood glucose levels and liver enzymes were found to be decreased with ELTI in STZ induced diabetic rats. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S- transferase (GST) and the levels of reduced glutathione (GSH) were also decreased, while an increase in the levels of thiobarbituric acid reactive substances (TBARS) were observed in pancreas and liver with ELTI treatment in STZ induced diabetic rats. Histopathology reveals that the protective effect of ELTI over STZ induced oxidative damage in both liver and pancreas. These results indicated that ELTI has more potential antioxidant effects on diabetic-induced oxidative stress.
Keywords: Oxidative Stress: Streptozotocin; Tylophora Indica Back to TOC