Hemorheological Indices and Glycated Hemoglobin in Type 2 Diabetes Mellitus

Renuka P*, Somnath Bag and Vinodhini V. M

Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram District- 603203, Tamil Nadu, India.

Corresponding Author E-mail: renukap@srmist.edu.in

Abstract: The use of HbA1c in diagnosis of diabetes mellitus by WHO and ADA has come under scrutiny. Aim: To study the erythrocyte index alterations and their relationship with HbA1c for proper interpretation of HbA1c values in diabetic subjects. Materials and methods: Data from 301 diabetic patients was collected. The parameters included were fasting plasma glucose, red blood cell count, hemoglobin level, hematocrit, glycated Hemoglobin (HbA1c), MCV, MCH, MCHC and RDW. Results: A negative correlation was found between HbA1c and MCV, MCH and MCHC and positive correlation with RDW. Conclusion: Hematological parameters like MCH, MCV and MCHC should be taken into account in interpreting HbA1c levels in diagnosis and management of pre diabetes and diabetes.

Keywords: Diabetes Mellitus; Glycated Hemoglobin; MCH; MCHC; MCV; RDW

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