Comparison between Moisturizing Cream Containing 10% Urea and 10% Lanolin in Petrolatum in Skin Hydration Improvement Among Elderly
Dwi Indria Anggraini1*, Rahadi Rihatmadja2 and Shannaz Nadia Yusharyahya21Faculty of Medicine, Universitas Lampung, Indonesia.
2Department of Dermatology and Venerology, Faculty of Medicine Universitas Indonesia, Indonesia.
Corresponding Author E-mail: dwiindriaanggraini6@gmail.com
Abstract: Inadequate xerosis treatment may result in complications. This study aimed to comparing the efficacy and side effects of moisturizing cream containing 10% urea and 10% lanolin in petrolatum for the treatment of xerosis in elderly. A randomized, double blind clinical trial was conducted in 35 elderly from a nursing home in Jakarta. Evaluation of skin capacitance (SC), specified symptoms sum score (SSRC), and pruritic degree were measured at baseline, week-2 and -4 after the start of therapy. Following a 2-week precondition period, each subject received a random moisturizer for each limb, to be applied twice daily. The percentage of SC increase at week-4 was significantly higher in limb receiving cream containing 10% urea than 10% lanolin/petrolatum (64.54% vs. 58.98%; p=0.036). The percentage of SSRC decrease at week-4 did not differ between groups (100%; p=0.089). Pruritus was equally improved in both groups at week-2, and completely diminished at week-4. Overall, the most frequent side effect was sticky feel, more common, but not statistically significant, in 10% lanolin/petrolatum group. After four-week application moisturizer containing 10% urea gave higher percentage of SC increase than 10% lanolin/petrolatum in the xerotic limbs of the elderly. Sticky feeling was more frequently found in 10% lanolin/petrolatum group, but statistically not significant.
Keywords: Elderly; 10% lanolin; petrolatum; 10% urea; xerosis. Back to TOC