Effect of “Nettle Oil” on Oxidative Damage to the Heart and Lungs Induced by Radiation
Marat Iztleuov1, Yerbolat Iztleuov2, Alma Yelubayeva1, Zarina Aleuova1, Zhanat Turganbaeva1, Zhanibek Madikhan1, Dana Sakypova1, Almagul Zhumasheva1 and Gulmira Iztleuova31Department of Natural Sciences, Faculty of Medicine, West–Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
2Department of Radiation diagnostics, Faculty of Medicine, West–Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
3Course of dermatovenerology, Faculty of Medicine, West–Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Corresponding Author E-mail: ermar80@mail.ru
Abstract: We studied the effect of "Nettle Oil" on radiation-induced oxidative damage in the tissues of the heart and lungs. The experiment was performed on 40 Wistar male rats divided into 4 groups. Animals of the first and third groups received intragastric sunflower oil at a dose of 2.5 ml/kg bodyweight for 14 days. Animals of the second and fourth groups - the drug "Nettle Oil" in the same amount and mode. Then, rats of the third and fourth groups, an hour after the last injection of oil, were exposed to gamma radiation (6 Gr). Irradiation toxicity was manifested by an increase in blood serum activity of aspartate, alanine aminotransferase, creatine phosphokinase, lactate dehydrogenase, total cholesterol, triglycerides, low-density cholesterol lipoproteins, atherogenic indices against the background of a decrease in high-density cholesterol lipoproteins. In the tissues of the heart and lungs, the amount of malondialdehyde increased and the activity of superoxide dismutase, catalase, glutathione peroxidase and the level of reduced glutathione and non-protein thiol decreased. The introduction of "Nettle Oil" prior to irradiation provided significant antioxidant protection. Antioxidant enzymes increased along with the levels of reduced glutathione and non-protein thiol, which is associated with a significant decrease in the level of malondialdehyde in the tissues of the heart and lungs.
Keywords: Heart; Ionizing radiation; Lung; “Nettle oil”; oxidative stress. Back to TOC