Ameliorative Effect of Camel Urotherapy to Cisplatin Induced Urinary Tract Subacute and Chronic Toxicity in Male Albino Rats

Hany Salah Mahmoud¹, Wael M. Elsaed^2,3, Howayda E. Khaled⁴, Tamer Mohamed Ezzat⁵and Menna Allah I. El Menyawi^6*

¹Center of Scientific Foundation for Experimental Studies and Research, Ismailia, Egypt,  41511

²Department of Anatomy and Embryology, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia

³Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

⁴Zoology Department, Faculty of Sciences, Suez University, Egypt

⁵Department of  Internal Medicine and Nephrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

⁶Medical Physiology Department, Faculty of Medicine, Suez Canal University, Egypt, 41511

Corresponding Author E-mail : mennaelmenyawi@med.suez.edu.eg

Abstract: Background: Camel urine has been widely used in desert area traditional medicine. It was considered as an alternative medicine to cure variable diseases. This present study aimed to investigate the ameliorative effect of camel urine against cisplatin induced subacute and chronic urinary tract toxicity in male Albino rats. Methodology: Thirty two rats were assigned randomly into four groups, eight rats each. Group I served as control, group II received only camel urine, group III injected with cisplatin and group IV injected with cisplatin and treated with camel urine for 2 months. Blood sera were collected at 1 month and 2 months interval for creatinine, urea and uric acid estimation. Moreover, urinary bladder and kidney were subjected to histochemical (masson's trichrome) and histopathological examinations. Results: There was significant (P<0.05) improvement in renal functions (creatinine, urea and uric acid) in cisplatin group treated with camel urine. Also, camel urotherapy induced significant histopathological improvement in urinary bladder and renal tissues deteriorated by the cisplatin. Marked reduction in fibrous tissue formation was detected in kidney and urinary bladder in cisplatin group treated with camel urine. Conclusion: Camel urine proved its safety when used alone and also its palliative and ameliorative effect in renal toxicity induced by cisplatin.

Keywords: Camel; Cisplatin; Kidney; Urine; Urinary Bladder

[ HTML Full Text]

Back to TOC