The Effectiveness of Triamcinolone Injection on Risk of Postoperative Operations with the Conjunctiva Autograft Technique and Its Association with Change of VEGF mRNA Expression
Purnamanita1, Budu2, Mochammad Hatta3, Muhammad Nasrum Massi3, Rosdiana Natzir4, A. M. Ichsan2and Hidayat Sujuti5

1Public Eye Health Centre Makassar, Indonesia

2Department of Ophthalmology Faculty of Medicine Hasanuddin University Makassar, Indonesia

3Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University Makassar, Indonesia

4Department of Biochemistry, Faculty of Medicine Hasanuddin University Makassar, Indonesia

5Department of Ophthalmology, Faculty of Medicine Brawijaya University Malang, Indonesia

Corresponding Author E-mail : hattaram@yahoo.com

Abstract: Objective: To evaluate the effectiveness of 20 mg subconjunctival injections of Triamcinolone and their relationship to changes in VEGF mRNA expression on the risk of postoperative recurrence Methods: Ten patients with stage II pterygium were divided into two groups, each group consisted of 5 samples given a subconjunctival injection of 20 mg Triamcinolone, and 5 samples given a placebo injection containing Balance Salt Solution (BSS), and venous blood was taken one week before excision. One week after injection, pterygium excision was performed using conjunctival autograft technique. One month postoperatively, VEGF mRNA expression was examined by taking venous blood and clinical changes after the injection was observed.Results: From 10 samples of pterygium patients, changes of expression in VEGF mRNA in the Triamcinolone group were 3.94 ± 0.96 and in the placebo group, the expression in VEGF mRNA was 1.27 ± 0.31, p = 0.006. The expression of mRNA in pterygium tissue in the Triamcinolone group was 8.98 ± 1.04 and in the placebo group it was 7.75 ± 0.62, p = 0.07. Clinical features appeared to be more minimal in the triamcinolone group than in the placebo group.Conclusion: The administration of subconjunctival injection of 20 mg Triamcinolone and the excision with conjunctival autograft is more effective in suppressing postoperative inflammation. It means that the likelihood of post-excision recurrence risk is smaller in this group compared to placebo

Keywords: mRNA VEGF; Pterygium; Recurrence; Triamcinolone

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