Effect of Angiotensin II Receptor Blocker Treatment on Adipokine of Corpulence
Feryal Hashim Rada
Department of Clinical Laboratory Sciences, College of Pharmacy, Al-Nahrain University, Iraq
Corresponding Author E-mail : fermsc33@yahoo.com
Abstract: Candesartan is one of the angiotensin II receptor blocker drugs that used for the treatment of hypertension. The plan of this prospective clinical study was to assess adequacy and acceptability of candesartan cilexetil (16 mg daily) in corpulent patients with essential hypertension. This research enrolled sixty-five corpulent patients (40 males and 25 females), aging (37 - 47 years) with stage 2 essential hypertension from Al yarmouk hospital in Iraq. Blood pressure (systolic and diastolic) ,body mass index (BMI) and clinical laboratory tests that included serum levels of lipid profile, leptin ,omentin-1 and chemerin were measured and studied at baseline (prior treatment) and after three months treatment with candesartan cilexetil (16 mg daily). The outcomes of this study declared that the treatment with candesartan cilexetil (16 mg daily) resulted in decreasing blood pressure (systolic and diastolic), P value < 0.001 and P value < 0.002 respectively, and in reducing serum levels of total cholesterol, triglyceride, leptin and chemerin as compared with their baseline levels. Contrarily, the treatment with candesartan cilexetil (16 mg daily) considerably elevated the serum level of omentin-1, P value < 0.01. Giddiness was the common adverse event presented in this study. The observation of this study on treatment of hypertensive patients with candesartan exhibited that this drug in addition to its adequacy in lowering blood pressure has a role in lessening blood levels of lipid profile and leptin and in amending blood level of olmentin-1.
Keywords: Adipocytokines; Candesartan; Corpulence; Hypertension Back to TOC