Effect of Mangrove (Rhizophora sp) Fruit Extract on Foam Cell Formation at the Initiation Stage of Atherosclerosis
Muhammad Yulis Hamidy1*
, Huriatul Masdar2 and Darmawi21Department of Pharmacology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia
2Department of Histology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia
Corresponding Author E-mail :yulis.hamidy@gmail.com
Abstract: To evaluate mangrove (Rhizophora sp) fruit extract effect on foam cell formation at the initiation stage of atherosclerosis. The study was conducted on 18 rats divided into 3 groups (n=6). Group 1 was given a standard diet, Group 2 was given a high cholesterol diet, and Group 3 was given a high cholesterol diet and mangrove fruit extract 500 mg/kg. The mangrove fruit extract effect on foam cell formation was assessed by histopathologic examination using hematoxylin eosin staining. The results showed that the number of foam cells was increased significantly in high cholesterol diet-fed rats compared to standard diet-fed rats (21.17 vs. 11.75). Mangrove fruit extract reduced this number remarkably (21.17 vs. 12.67). In conclusion, mangrove fruit extract inhibits the formation of foam cells at the initiation stage of atherosclerosis.
Keywords: Atherosclerosis; Foam Cell; Mangrove Fruit Extract Back to TOC