Correlation of Body Mass Index and Some Hormones (Estradiol, Luteinizing, Follicle Stimulating Hormones) with Polycystic Ovary Syndrome among Young Females [20 to 35 Years]
Bursha A. J. Al-Juaifari and Essam F. Al-JumailiGenetic Engineering and Biotechnology Institute for Postgraduate Studies/ University of Baghdad, Baghdad-Iraq
Corresponding Author E-mail : Profdressamaljumaily@gmail.com
Abstract: Polycystic Ovary Syndrome (PCOS) is the most common heterogenous complex endocrine disorder. It is affecting approximately 15 % of the women in their reproductive age. The exact cause of the PCOS is unknown, but genetic factors, environmental and endocrine factors playsa important role in the etiology of PCOS.This study was conducted between first November 2018 and May 2019 in the laboratories of the Institute of Genetic Engineering and Biotechnology for Postgraduate Studies – University of Baghdad, and the sample collected from various laboratories in Baghdad.The study included (50) women with Polycystic Ovary Syndromeand (50) women apparently healthy control fromunmarried Iraqi women between (20-35) years old and take the weight and length to get the Body Mass Index, the result showed slightly increased in Body Mass Index(Non-significant) between two groups and get the full data from every patients by questioner form.The analysis of hormones 17B - Estradiol, Luteinizing hormone, Follicle stimulating hormone, Tri-iodothtronine, Thyroxin and Thyroid stimulating hormonecarried out by using IMMULITE 2000 systems random excess device, the results show high significant differences in the levels of serumEstradiolandLuteinizing hormonebetween two groups (P<0.01) and no significant difference in level of serumFollicle stimulating hormone.The findings also indicate a slight rise in serum concentrationsThyroid stimulating hormoneand non-significant between two groups and significant decrease in the level of serum Thyroxin(P<0.01) between women with Polycystic Ovary Syndrome and control group. The results showed significant positive correlation between 17B - Estradiol andLuteinizing hormone which gave correlation coefficient 0.67 (p-value <0.01) and negative correlation with Thyroxinwhich gave correlation coefficient -0.23 (p-value <0.01), while other hormones Follicle stimulating hormone, Tri-iodothtronineand Thyroid stimulating hormone no significant difference in patient with Polycystic Ovary Syndrome and apparently healthy control.Within the limitation of this study we can conclude: the concentrations of estrogen showed a elevated rise against ordinary checks in Polycystic Ovary Syndrome instances. High concentrations of androgens in peripherally converted Polycystic Ovary Syndrometo estrogens may contribute to their enhanced concentration.
Keywords: Body Mass Index; Estradiol(E2); Follicle Stimulating Hormone (FSH); Luteinizing Hormone (LH); Polycystic Ovary Syndrome; Tri-iodothtronine (T3) Back to TOC