Anti Ulcerogenic and Anti-Oxidant Activity of Alpinia Galanga Rhizomes Aqueous Extract in Indomethacin Induced Gastric Mucosal Damage in Wistar Albino Rats
I.Israel Raja Johnley1
, G. Somasundaram2, Kartik J Salwe3*and K. Manimekalai31Department of Pharmacology, Government Thoothukudi Medical College, Thoothukudi – 628001
2Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry - 605 502
3Department of Pharmacology, Mahatma Gandhi Medical college and research institute, Sri Balaji Vidyapeeth, Puducherry-607403
Corresponding Author E-mail : kartiksalwe@gmail.com
Abstract:
Peptic ulcer disease is common diseases of the gastrointestinal tract that occur with long term use of NSAIDs. Currently available drugs for acid peptic disease shows side effects, relapses after discontinuation and drug interactions. Many Indian medicinal plants and their active compounds are used for prevention and treatment of Peptic ulcer.To evaluate the anti-ulcerogenic and anti-oxidant activity of Alpinia galanga rhizome in Wistar Albino rats.Animals were divided into 4 groups with 6 animals in each. Group 1 received only vehicle 1% CMC orally for 7 days. Group 2 received 1% Carboxyl methyl cellulose (gastric mucosal injury was induced by Indomethacin in this group) orally for 7 days. Group 3 received Alpinia galanga rhizomes extract (AGRE) 200 mg/kg orally for 7 days. Group 4 received Ranitidine 20 mg/kg orally. On 7th day, overnight fasted rats were given last dose of drugs and after 60 minutes of the last dose, gastric mucosal damage was produced by Indomethacin 40 mg/kg through gastric lavage, in all groups except group 1. Six hours later, calculation of ulcer score was done using Ulcer index and percentage inhibition method. The number and severity of ulcers were recorded with arbitrary scale. The antioxidant action of AGRE was also assessed.Rats pre-treated with extract of Alpinia galanga rhizomes showed significant decrease in ulcer index and percentage inhibition of ulcers was comparable with Ranitidine. Also, there was a significant increase in antioxidant levels in rats treated with Alpinia galanga rhizomes extract showing its antioxidant property.The extract shows significant antiulcer activity against Indomethacin induced gastric ulcers probably due to its antioxidant property.
Keywords: Alpinia galanga rhizomes; Acid peptic Disease; Indomethacin; Ranitidine Back to TOC