Assessment of Hepatoprotective Activity of Rajata Bhasma in CCl¬4 Induced Hepatotoxicity Rats

Anand Prakash Rai¹*, Shalini Tripathi² and Om Prakash Tiwari³

¹Institute of Pharmacy, H.C.P.G College, Bawan Begha, Varanasi (U.P.) Pin-221102

²Rameshwaram Institute of Technology and Management, Sitapur road, Lucknow (U.P.) Pin-227202

³Varanasi college of Pharmacy, Near Babatpur Airport, Varanasi (U.P.) Pin-221105

Corresponding Author E-mail: anandphd256@gmail.com

Abstract: Rajata Bhasma (RB) is an Ayurvedic formulation and used for the treatment of liver disorders. Till date scientific validation according to modern tool of RB has been not performed. Hence it was planned to evaluate the hepatoprotective activity of RB in CCl­₄ induced liver cirrhosis rats. The different formulation RB1 (9 puta) and RB2 (17 puta) were prepared by following classical methods. The SGOT, SGPT, ALP, ACP, total bilirubin and direct bilirubin in blood significantly enhance in CCl₄ treated rats compared to normal group rats. After treatment with the different doses of RB1 (50 mg/kg and 100 mg/kg) and RB2 (50 mg/kg and 100 mg/kg) significantly decreased the CCl₄ induced alteration in SGOT, SGPT, ALP, ACP, total bilirubin and direct bilirubin in blood. The RB1 and RB2 treated rats significantly increased the level of catalase, glutathione peroxidase, superoxide dismutase enzyme, whereas lipid peroxidation was decreased, when compared to CCl₄ treated group rats. Theses property confirmed the antioxidant properties of RB. The findings suggest that hepatoprotective activity of RB may be due to free radical scavenging property.

Keywords: Rajata Bhasma; hepatoprotective activity; antioxidant actiivit; CCl₄

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