Antihyperglycemic Activity of Murraya koenigii Leaves Extract on Blood Sugar Level in Streptozotocin-Nicotinamide Induced Diabetes in Rats
Rohan S. Phatak1*
, Chitra C. Khanwelkar1, Somnath M. Matule1, Kailas D. Datkhile2 and Anup S. Hendre31Department of Pharmacology, Krishna Institute of Medical Sciences, Karad-415110, Maharashtra, India
2Department of Molecular Biology and Genetics, Krishna Institute of Medical Sciences, Karad-415110, Maharashtra, India
3Department of Biochemistry, Krishna Institute of Medical Sciences, Karad-415110, Maharashtra, India
Corresponding Author E-mail: phatak.rohan1983@gmail.com
Abstract: The effects of Murraya koenigii leaves are very less studied in streptozotocin-nicotinamide (STZ-NA) induced diabetes rat model, in spite of several studies reported its antidiabetic effects in alloxan and STZ induced diabetes. The present study was undertaken to assess the effects of Murraya koenigii leaves extract on the blood sugar level (BSL) of STZ-NA diabetic rats. Experimental diabetes was induced by STZ injection intraperitoneally (i. p) after 30 min of NA injection i. p in all groups apart from normal control group. Group I (normal control) and Group II (diabetic control) rats received distilled water. Group III rats treated Metformin, Group IV and Group V rats treated Murraya koenigii aqueous extract and Murraya koenigii methanolic extract respectively. BSL and body weights of rats were measured at each week of the period of 28 days. Our results indicate that oral administration of Murraya koenigii reduces BSL significantly compared with the diabetic group. No weight loss was observed in all groups. The findings of the present study suggest that Murraya koenigii is proven as anti-diabetic agent in diabetic rats.
Keywords: Blood Sugar Level; Diabetes; Murraya Koenigii; Streptozotocin-Nicotinamide Back to TOC