Paraoxonase Activity in Prehypertension and its Relation to Oxidative Stress
Tripti Saxena1, B. K. Agarwal1, V. K. Sharma2, Sabiha Naz1 and Pooja Lanke11Deparment of Biochemistry, Gandhi Medical College Bhopal, India.
2Deparment of Medicine, Gandhi Medical College Bhopal, India.
Abstract: Hypertension (HTN) is a major cause of stroke, ventricular hypertrophy, congestive heart failure, atherosclerosis, end stage renal disease and peripheral vascular disease. Since, Prehypertension is one step towards hypertension, the same are the consequences. Serum paraoxonase (PON 1) is an HDL bound enzyme exhibiting antiatherogenic properties .PON 1 activity is inversely related to the risk of developing atheroscelerosis. Free O‚ radicals react with membrane lipids to form lipid hydroperoxides, a destructive process known as lipid peroxidation. Lipid hydroperoxides decompose to form a variety of products including Malondialdehyde (MDA), which is used as an indicator of oxidative damage of cells and tissues. Endogenous antioxidants enzymes such as superoxide dismutase (SOD) counteract the oxidative damage preventing Oxidative stress. Recently hypertension has been considered a state of oxidative stress that can contribute to the development of atheroscelerosis and other hypertension induced organ damage. In this study, serum paraoxonase activity and oxidative stress were monitored in 100 patients with Prehypertension and 100 sex matched healthy controls. Prehypertensives are again classified into obese and smokers. The activity of PON was significantly (p<0.001) low as well as SOD was also significantly (p<0.001) low in both obese and smokers with Prehypertension where as MDA level was significantly (p<0.001) increased in both obese and smokers with Prehypertension as compared to controls .Our study showed the increased oxidative stress and decreased paraoxonase antioxidant activity in Prehypertensives when compared to controls. Thus, the estimation of Paraoxonase activity and Oxidative stress will prove to be an emerging marker in prognosis of Prehypertension.
Keywords: Paraoxonase; Superoxide dismutase; Malondialdehyde Back to TOC