Relationship of Interleukin-6 Trans-Signaling and Coronary Heart Disease in Young Adults: a Case-Control Study in Indonesia
Jajang Sinardja1, Eryati Darwin2, Eva Decroli3 and Djong Hon Tjong41Program Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia.
2Department of Histology, Faculty of Medicine, Andalas University, Padang, Indonesia.
3Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia.
4Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia.
Corresponding Author E-mail: sinardja@yahoo.com
Abstract: Interleukin-6 (IL-6) has been reported to be related to coronary heart disease (CHD). It is proposed that the IL-6 trans-signaling pathway is responsible for the inflammatory effect in diseases, including CHD. In Asian countries, CHD tends to occur in younger age. However, no study has yet been done to assess the relationship between IL-6 trans-signaling pathway and young CHD patients in Indonesia. To assess whether there is a relationship between the levels of some components in the IL-6 trans-signaling pathway, including soluble interleukin-6 receptor (sIL-6R), soluble glycoprotein 130 (sgp130), and intercellular adhesion molecule 1 (ICAM-1) and CHD in young adults. A case-control study was conducted including 33 young CHD patients and 33 non-CHD patients as the control group (age and sex matched with CHD group) at Eka Hospital Pekanbaru, Indonesia, from July to November 2018. CHD was confirmed by coronary angiography, while non-CHD patients were subjects with normal ECG, without history of chest pain and family history of CHD. All participants were checked for sIL-6R, sgp130, and ICAM-1 serum levels using ELISA assays tests. The results were evaluated statistically using Student’s t test. The sIL-6R level tended to be higher in the CHD group compared to the control group (70.19+49.38 ng/ml vs 49.42+38.79 ng/ml) but did not reach statistical significance (p=0.062). The sgp130 level was 428.38+358.79 ng/ml and 474.08+389.43 ng/ml in CHD and control group, respectively (p=0.622). While the ICAM-1 level was 1829.53+1882.37 pg/ml and 2078.16+1595.25 pg/ml in CHD and control group, respectively (p=0.565). The IL-6 trans-signaling pathway, reflected by sIL-6R, sgp130, and ICAM-1 serum levels, was not significantly related with CHD in young adults.
Keywords: Coronary Heart Disease; Intercellular Adhesion Molecule-1; Interleukin-6 Trans-Signaling; Soluble Glycoprotein 130; Soluble Interleukin-6 Receptor; Young Adults Back to TOC