Ethanol Extraction of Hoya Carnosa Leaves Improved Stroma of Middle Ear Epithelium Infected by Pseudomonas Aeruginosa

Made Lely Rahayu¹, I. Made Bakta², Wayan Suardana¹, Nyoman Mantik Astawa³, I. G. K. Arijana⁴ and I. Ketut Tunas⁵

¹Department of Otorhinolaryngology-Head and Neck surgery Faculty of Medicine Udayana University/Sanglah General Hospital Denpasar, Bali, Indonesia.

²Departement of Internal Medicine Faculty of Medicine Udayana University/Sanglah General Hospital Denpasar, Bali, Indonesia.

³Pathobiology Laboratory of Faculty of Veterinary Medicine Udayana University, Bali, Indonesia.

⁴Department of Histology Faculty of Medicine Udayana University, Bali, Indonesia.

⁵Department of Public Health, Faculty of Health, Science and Technology, Dhyana Pura University, Bali, Indonesia.

Corresponding Author E-mail: madelelyrahayu@gmail.com

Abstract: Hoya carnosa leaves or tebel-tebel leaves are known by the Balinese people in the countryside to treat middle ear infections in the medical language, otitis media or “curek” in the Balinese language. The study is true experimental randomized posttest-only control group design to evaluate the impact of ethanol extract sample as antibacterial. As antibacterial, the extract has an impact on the thickness of stroma middle ear epithelium with otitis media due to Pseudomonas Aeruginosa. The result showed average mean thickness stroma in the treatment group lower than controls.

Keywords: Ethanol Extract; Hoya Carnosa; Middle Ear; Pseudomonas Aeruginosa; Stroma

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