Synthesis of penicillin derivatives and study of their biological antibacterial activities
Lakhdar Sekhri*, Mohammed Lazhar Kadri, Choula Samira and Moussa SenigraDepartment of Chemistry, Faculty of Sciences, University of Kasdi Merbah, Ouargla
Corresponding Author E-mail:sekhril@yahoo.fr
Abstract: The novel penicillin derivatives Amp-1 and Amx-1 have been synthesised via diazotising aniline with sodium nitrite in a medium of hydrochloric acid and the resulting phenyldiazonium chloride couples to ampicillin and amoxicillin. Esterification of ampicillin and amoxicillin with ethanol and isopropanol yielded the penicillin derivatives Amp-2, Amp-3, Amx-2, and Amx-3. The penicillin derivative Oxa-1 was successfully synthesized by nitration of oxacillin. These penicillin derivatives (except Oxa-1) showed significant activity against all the bacteria tested, Escherichia Coli, Streptococcus pneumonia, Protius, Staphylococcus aureus and Pseudomonas.
Keywords: Penicilin derivatives Amp-1; Amx-1; Antibacterial activity Back to TOC