1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one Attenuates Oxidative Trauma and Recuperate Beam Walk and Adhesive Removal Behavior in MPTP Parkinsonian Mice Model
Mohankrishna Ghanta1
, Elango Panchanathan1, Bhaskar V. K. S. Lakkakula2, Anbumani Narayanaswamy3, Yogeshkumar Murkunde4 and Shonam Tamrakar41Department of Pharmacology, Sri Ramachandra Medical College, Sri Ramachandra Institute of Higher Education and Research - DU, Chennai-600116, Tamil Nadu, India.
2Department of Molecular Genetics, Research Division, Sickle Cell Institute Chhattisgarh, Raipur- 492001, Chhattisgarh, India.
3Department of Microbiology, Sri Ramachandra Medical College, Sri Ramachandra Institute of Higher Education and Research - DU, Chennai-600116, Tamil Nadu, India.
4CEFTE, Sri Ramachandra Institute of Higher Education and Research - DU, Chennai-600116, Tamil Nadu, India.
Corresponding Author E-mail: drpelango@yahoo.com
Abstract: Recent researches have suggested 1H-[1,2,4] oxadiazolo [4,3-a]quinoxalin-1-one (ODQ), a soluble guanylate cyclase inhibitor may attenuate motor impairments in Parkinson's disease (PD). The antiparkinsonian activity of ODQ were studied on motor abnormalities induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to provide a better understanding of this drug group. The objective of the present study is to evaluate the effect of ODQ on behavioral parameters such as Beam walk test, Adhesive removal test and to assess the biochemical changes due to ODQ against MPTP induced PD mice model. Eighteen C57BL/6J male mice were included in the study, divided into three groups of 6 each. Group A mice were treated with vehicle (Normal saline). Group B mice were subjected to MPTP sub acute protocol. Group C mice were treated with MPTP as according to sub acute protocol and administered with ODQ subcutaneous injection after final MPTP dose. Behavioral tests like Beam walk test, Adhesive removal test, along with Biochemical correlation were done using standard methods. Narrow beam walk and adhesive removal behavior were significantly reversed, and Superoxide dismutase (SOD) levels were enhanced in ODQ treated group compared to MPTP intoxicated mice group. Soluble guanylate cyclase inhibitor ODQ, could be a potential treatment for maintaining the balance of antioxidant and oxidant biochemical environment during oxidative stress which may be helpful for treating PD, targeting one or more factors of its multiple etiological factors.
Keywords: Behaviour; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; Parkinson's Disease; Superoxide Dismutase; MPTP Back to TOC