Pathological Risk Factor Profile for Enucleated Retinoblastoma at Sanglah General Hospital

Putu Yuliawati¹ and Ni Putu Ekawati²  

¹Department of Ophthalmology, Faculty of Medicine Udayana University, Sanglah General Hospital, Denpasar, Indonesia.

²Department of Pathology Anatomy, Faculty of Medicine Udayana University, Sanglah General Hospital, Denpasar, Indonesia

Corresponding Author E-mail: putu.yulia@gmail.com

Abstract: Retinoblastoma is a primary intraocular tumor on childhood. It has a good prognosis with early detection. Aim of this study is to know Pathological Risk Factors (PRF) profile of enucleated retinoblastoma at Sanglah General Hospital. This study is an observational retrospective study based on patient’s medical record and pathological examination. Twenty patients were included in this study, 50% were female and 50% male within age ranging from 7 month – 12 years old. Unilateral retinoblastoma was found in 18 patients (90.5%), bilateral retinoblastoma was found in 2 patients (9.5%). Majority PRF profile found that cancer cell invasions was 60% choroid infiltration and 45% of anterior segment invasion, 60% of optic nerve infiltration, and 50.1% scleral invasion. Tumor cell aggregation showed 61.9% poorly differentiated malignant cells. None of the patients had family history of retinoblastoma. This study revealed optic nerve and choroid invasion were the major PRF found in retinoblastoma, but there is a significant association between scleral infiltration and tumor cell differentiation (p = 0.025). There was no statistical difference of PRF based on age, gender, and laterality.

Keywords: Enucleated Retinoblastoma; Pathological Risk Factors; Retinoblastoma; Tumor Differentiation

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