Zingiber Officinale Alleviates Maternal and Fetal Hepatorenal Toxicity Induced by Prenatal Cadmium
Gamal S. Abd El-Aziz1
, Hesham N. Mustafa1, Hamid Abdulraouf Saleh1 and Magdy M. O. El-Fark21Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
2Department of Anatomy, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Corresponding Author E-mail: hesham977@hotmail.com
Abstract: This study was designed to address the protective effects of Zingiber officinale on the toxic outcomes of prenatal Cadmium administration on pregnancy outcome. Pregnant female Sprague-Dawley rats were randomly divided into four groups (eight rats/each), control group received distilled water, 2nd group treated with 8.8 mg of CdCl2/kg b. wt, 3rd group treated with 250 mg of Zingiber officinale/kg b. wt, and 4th group treated with 250 mg of Zingiber officinale/kg b. wt, followed by 8.8 mg of CdCl2/kg b.wt. Daily body weight of pregnant was recorded from GD1-GD20, and then pregnant rats were sacrificed at GD20. Samples of maternal and fetal livers and kidneys were processed for histological examination. Administration of Cd to pregnant rats showed adverse effects on pregnant mothers and their fetuses; reduced maternal weight gain, reduced absolute organ weights, reduced fetal growth parameters and placental weights together with altered histological appearance of the maternal and fetal livers and kidneys. While co-administration of Zingiber officinale showed an improvement of these toxic alterations. Zingiber officinale through its antioxidant activity could be beneficial against toxic outcomes of Cd exposure during pregnancy.
Keywords: Cadmium; Fetal Toxicity; Maternal Toxicity; Zingiber Officinale Back to TOC