Effect of Hyperbaric Oxygen Therapy to Improve Serum Albumin for Patients with Diabetic foot Ulcers
Hendry Irawan1
, I. Nyoman Semadi2 and Anita Devi31General Surgery Department, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.
2Thorax and Cardiovascular Surgery Department, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.
3Hyperbaric Oxygen Therapy Department, Sanglah General Hospital, Denpasar, Bali, Indonesia.
Corresponding Author E-Mail: hendry_irawan@rocketmail.com
Abstract: Diabetic foot ulcers (DFUs) are the most common musculoskeletal infections and complications in patients with diabetes mellitus. DFUs require comprehensive multidisciplinary treatment and also long period time of healing. Hyperbaric oxygen therapy (HBOT) is one of adjuvant therapy for DFUs with promising results. The aim of our study was to test the hypothesis that serum album in patients with DFU is affected by HBOT. We used randomized pre- and post-test control group design with permuted block from all patients who met the inclusion criteria. We recruited 36 patients who then divided into two groups, HBOT and non HBOT group. Each patient’s blood sample was taken twice, before and after therapy. HBOT group showed significant increase in serum albumin, from 2.96 ± 0.43 g/dL to 3.51 ± 0.46 g/dL (p < 0.0001) while non HBOT group did not show any significant change, from 2.92 ± 0.51 g/dL to 3.01 ± 0.41 g/dL (p = 0.440). We also calculate the effect size of serum albumin increased level. The effect size was differed significantly between HBOT and non HBOT groups (0.55 ± 0.38 g/dL and 0.09 ± 0.49 g/dL, p = 0.007). There is a significant increase in serum albumin level in DFUs patient who underwent HBOT therapy.
Keywords: Diabetic Foot Ulcer; Hyperbaric Oxygen Therapy; Serum Albumin Back to TOC