Sperm Na+ K+-ATPase and Ca2+-ATPase Activities: A Potential Predictive Parameter of Sperm Motility Disorder in Infertile Men

Silvia W Lestari^1,4, Manggiasih D. Larasati², Indra G. Mansur^1,4 and Ria Margiana^3,4

¹Department of Medical Biology, Faculty of Medicine Universitas Indonesia.

²Master Program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia.

³Department of Anatomy, Faculty of Medicine Universitas Indonesia.

⁴The Indonesian Reproductive Medicine Research and Training Center, Ina-Repromed.

Corresponding Author E-mail: finallysilvia@gmail.com

Abstract: Current highlight on the etiology of male infertility is a disorder in sperm motility  which is caused by ion homeostasis imbalance involving the ubiquitous multifunctional transmembrane protein, Na⁺K⁺-ATPase and Ca²⁺-ATPase enzymes. The emphasis of this review is evaluating the use of sperm’s Na⁺K⁺-ATPase and Ca²⁺ATPase activity as predictive parameters of sperm motility disorder. To this purpose, a computerized search of PubMed database was performed and obtained data were reviewed in this paper. The retrieved studies were laboratory experiments involving human and mice sperm as the subjects. Na⁺ K⁺-ATPase and Ca²⁺-ATPase play an essential role in sperm motility by controlling ion homeostasis. Na⁺ K⁺-ATPase maintains the intracellular pH by transporting 3 Na⁺ out and 2 K⁺ into the cell, whereas Ca²⁺-ATPase extrudes Ca²⁺ from the cell. The impairment of these enzymes and its isoforms, Na⁺ K⁺-ATPase α4 and PMCA4 expression were proved to decrease sperm motility.

Keywords: Ca²⁺ATPase Male Infertility; Na⁺ K⁺-ATPase; Sperm Motility;

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