A Systematic Review of Pharmacological Therapies for Sickle Cell Disease

H. S. Nikhar*, S. U. Meshram and G. B. Shinde

Department of Microbiology, R.T.M. Nagpur University, L.I.T Premises Nagpur- 440 033 India.

Abstract:

This review was carried out to understand various issues concerned with the patients of sickle cell disease (SCD). An attempt has been made to review the literature with respect to the multiple complications experienced by the SCD patients, variety of pharmacological therapies used throughout the world for SCD management. The literature highlighted the lack of reliable prevalence statistics, lower use of diagnostic measures, especially in rural areas. The literature indicated that varieties of medicinal plants are used regularly for the management of SCD related complications, such as sickling, infections, pain crisis, etc. Although, Bone marrow transplant, the only curative therapy and genetic counselling, have shown promising results for effective management of SCD, now a days people are using alternative pharmacological therapies for SCD management

Keywords: Sickle cell disease; pharmacological therapies; sickling; pain crisis; Bone marrow transplant

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