Amelioration of Cisplatin - Induced Nephrotoxicity by Roots of Anthocephalus Cadamba
Kaveripakam Saisruthi and Adikay SreedeviPharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam (Women’s University), Tirupati, Andhra Pradesh, India.
Corresponding Author E-mail: sruthisai7@gmail.com
Abstract: The present study was aimed to evaluate the nephroprotective potential of ethanolic extract of roots of Anthocephalus cadamba. Ethanol extract of roots of Anthocephalus cadamba was prepared by hot extraction and subjected to preliminary phytochemical and acute toxicity studies. The nephroprotective potential of extract was evaluated in Wistar rats at two dose levels of 200 and 400 mg/kg b. w. Nephrotoxicity was induced by injecting cisplatin (5 mg/kg b. w. i.p). Nephroprotective potential was assessed by determining serum creatinine, Blood urea nitrogen, Urinary total protein, Creatinine clearance, lipid peroxidation and antioxidant levels. Extract significantly attenuated nephrotoxicity induced by cisplatin which was confirmed by reducing levels of serum markers, urinary total protein, lipid peroxidation and increased creatinine clearance. Extract also compensated deficits in the renal antioxidant system. Histological studies substantiated the biochemical parameters. Thus it can be concluded that Anthocephalus cadamba has a potential role in the abatement of cisplatin-induced nephrotoxicity.
Keywords: Anthocephalus cadamba Cisplatin;Nephroprotective; Back to TOC