Synthesis, Spectral Evaluation and Potential Antimicrobial Screening of some Substituted Thiosemicarbazides and Substituted Thiosemicarbazones Under Microwave Irradiation and Classical Heating
Alok. Pareek*, P. E. Joseph and Daya S. SethSchool of Chemical Sciences, Department of Chemistry, ST. John’s College, Agra - 282 002 India.
Abstract: A convenient synthesis of substituted thiosemicarbazides & substituted thiosemicarbazones containing different functional groups have been synthesized by two different ways one is conventional heating method and other is microwave irradiation (MWI) method “Green Chemistry” .substituted thiosemicarbazides have been obtained by N(R)-malon anilic acid hydrazides (1a,1b) with substituted phenyl isothiocyanate in alcoholic medium and the substituted thiosemicarbazon-es have also been obtained by these two different techniques, derived from substituted aromatic aldehydes & ketone with substituted thiosemicarbazides (1a,1b) in ethanolic solution and few drops of glacial acetic acid was added. The results of the synthesized compounds in terms of yield, time, rapid reaction are compared. Some of the synthesized compounds(2a,2b,2d,2e,2h, 2i,3d,3f,4e,4f) were screened for their anti-bacterial activity against Staphylococcus aureus and Escherichia coli micro organisms. The structures of the synthesized compounds were characteri-zed by their physical properties, elemental analysis, spectral studies viz: IR, 1H NMR.
Keywords: Thiosemicarbazides; Thiosemicarbazones; Antibacterial Screening; Spectral Analysis Back to TOC