Epidemiology of Hepatitis B Virus Genetic Diversity Vs and Diagnostic Molecular Markers of Hepatitis C Virus Core Gene
Shahrzad Nokhbeh ZaeemIslamic Azad University of parand, Parand, Iran.
Corresponding Author E-mail: shahezad.nz@gmail.com
Abstract: Hepatitis B Vs in most cases appears to chronic liver inflammation and liver in the long term can lead to cirrhosis or cancer. Attempts have been made to treat and control the disease as a major health problem in the world and is considered done. Recent studies on the biology of the virus cause diagnostic markers including hepatitis B virus genotypes Vs and seeking nuclear gene has been mutated strains. On the other hand the distribution of genotypes of the virus in different countries and the relationship between genotype and different serotypes in the world. Determine the different types of hepatitis genotype should be determined in each country of the region, such as determining the therapeutic protocol to implement antiviral therapy based on genotype will be different. In this study published papers related to the prevalence of hepatitis B virus genotypes and cultivars Vs mutant genotypes were searched. The results show that in patients with hepatitis B genotype dominant form in Asia C In northern and central Europe genotype A, in the countries around the Mediterranean and East Europe genotype D in Latin America genotype H and F, Genotypes in Africa a and E In patients with genotype 1 Hepatitis C virus. Also, in the United States and northern Europe, genotype 2 in sub-Saharan Africa and Central and West Africa and South-East Asia, genotype 3 in sub-Saharan Africa and the Far East and the Indian subcontinent, genotype 4 in the Middle east and Africa, genotype 5 in south Africa and genotype 6 in south China and south east Asia are high. Cirrhosis of the liverin genotype 1 and 4 are more common. With the arrival of protease inhibitors of Hepatitis C virus in the field of treatment and drug resistance observed in these types of treatments, studied the genome of hepatitis C in the presence of mutations associated with resistance to protease inhibitors has become important. In hepatitis C from the marker gene polymorphisms I LB 28 and genotype, gene polymorphisms ITPA to identify mutations associated with resistance to inhibitors are used.
Keywords: epidemiology; genotype; Hepatitis B Vs;molecular markers; Back to TOC