Role of MSX1 Gene in Orofacial Clefting : A Systematic Review

C. Deepak¹ and Arvind Ramanathan²

¹Department of Orthodonics, Bharath University Chennai, India.

²Sree Balaji Dental College and Hospital  Bharath University Chennai, India.

Abstract: MSX1 gene is among the Homeo box genes . The Master genes that control the downstream genes and are involved in the patterning of the face . MSX 1 deficient  mice have shown to have cleft palate and missing teeth . Several studies have been done , which have shown a  relationship between non syndromic cleft lip and palate and the MSX1 gene .  As Human studies on MSX1 and non syndromic clp are rare , this systematic review was done to see if there were sufficient literature to support the same . Three search data bases were taken , , Pubmed , Science direct and Cochrane were searched using the key words .  Pub med showed 5  , Science direct 79 and Cochrane 1 articles. Further  using the inclusion criteria , 5 articles were selected . Human studies involved populations from across the world .

Keywords: Non Syndromic cleft lip and palate MSX1 gene; systematic review;

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