Comparison of Antihypertensive and Antioxidative Effect of Mahogany (Swietenia Mahagoni (L.) Jacq.) Seed Extract and Purple Sweet Potato (Ipomoea Batatas) Tuber Extract on Rodent Model of Hypertension
I. Made Jawi1, A. N. Mahendra1, A. A. N. Subawa2, I. W. P. Sutirta Yasa2 and W. G. Gunawan31Department of Pharmacology and Therapy and Department of Clinical Pathology.
2Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia.
3Department of Natural Materials Chemistry, Udayana University, Denpasar-Bali.
Corresponding Author E-mail: made_jawi@yahoo.co.id
Abstract: Most herbal remedy uses in the society are not supported by sound scientific evidences. The purpose of this study was to demonstrate antihypertensive and antioxidative effect of mahogany (Swietenia mahagoni (L.) Jacq.) seeds extract compared to purple sweet potato tuber aqueous extract in hypertensive rats. This study used pre-test and post-test control groups design. Fourty two rats were allocated into 7 groups. The control group was given NaCl for 4 weeks on a daily basis. Treatment groups were given NaCl and also aqueous extracts of mahogany seed with the dose of 100 mg and 200 mg, mahogany seed ethanolic extracts with the dose of 100 mg and 200 mg, and aqueous extracts of purple sweet potato tuber with the dose of 100 mg and 200 mg for 4 weeks. Before the commencement of treatments, systolic blood pressure (SBP) and blood MDA level were examined. Measurements of SBP were also done every 3 days during the treatment period. After 4 weeks of treatment, SOD and MDA level in blood were examined. There are significant decreases in SBP and blood MDA, and significant increases in SOD levels (p< 0.05) in all treatment groups.
Keywords: antihypertension; antioxidant Mahogany seed; purple sweet potato; Back to TOC