Adhesion Prevention by Peritoneal Administration of Herbal Hydrogel
Anvar Elyasi1,2, Marzieh Soheili2, Khosro Setayeshi2, Shirin Honarmand1 and Katayoun Derakhshandeh3,41Department of Surgery, Faculty of Medicine, Kurdistan University of Medical Sciences, Kurdistan, Iran.
2Department of Surgery, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3Department of Pharmaceutics, Faculty of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran.
4Department of Pharmaceutics, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Corresponding Author E-mail: Kderakhshandeh@kums.ac.ir
Abstract: Peritoneal adhesions are pathological fibrotic bands developing after mesothelial damage which causes different problems in the patients. The aim of this study was to compare the anti-adhesion efficacy of a herbal structure made from Psylium seeds with a commercially available formulation named Pluronic both in the form of hydrogel in a rat cecum abrasion model. The rat model utilized a cecal abrasion and abdominal wall insult surgical protocol. Psylium hydrogel treatment was applied by syringe to coat both the cecal and the abdominal wall insults, while other animals were treated with Pluronic applied to the cecal injury. Control animals did not receive any treatment. Animals were sacrificed after 21 days of laparotomy and adhesion severity was quantitatively graded according to macromorphological characteristics. Histological analysis was also performed for all animals. Psylium treated animals showed significantly lower adhesion scores than other groups (P<0.05), while Pluronic did not demonstrate any noticeable results. In conclusion, Psylium hydrogel showed a significantly decreased adhesion score compared with the Pluronic and control groups. However, Psylium compared with all adhesion formulations and barriers offer natural structure as well as ease of application and ability to conform to complex tissue geometries that could provide surgeons with another prophylactic treatment for preventing abdominal adhesions.
Keywords: Peritoneal adhesion; Psylium hydrogel; herbal formulation Back to TOC