Evaluation of Antidepressant Activity of Ethanolic Extract of Alangium Salviifolium (L. F.) Wangerin in Swiss Albino Mice.
Shashikumara1, Prathima. C2 and Mohammed Sibgatullah31Department of Pharmacology, Chamarajanagar Institute of Medical Sciences, (CIMS).Chamarajanagar.
2Department of Pharmacology, J. S. S Medical College, (A constituent college of JSS University), SS Nagar, Mysore-570015.
3Drug safety physician Vigimedsafe Hyderabad.
Corresponding Author E-mail: sibgatullah2@yahoo.com
Abstract: To evaluate the in vivo antidepressant activity of Ethanolic extract ofAlangium salviifolium (L. f.) Wangerin leaves (EASL) in Swiss albino mice. Ethanolic extract of Alangium salviifolium (L. f.) Wangerin (EASL) leaves were prepared by a continuous method using Soxhlet apparatus. The extract was subjected to phyto-chemical screening followed by acute oral toxicity studies in mice. EASL in the doses of 100 and 200 mg/kg body weight was administered to test groups 1 and 2 respectively. Imipramine hydrochloride 15mg/kg body weight was administered to Standard group by oral route. Test group 3 received 100mg/kg (Per. Oral) of EASL + 10mg/kg (Per.oral) of Imipramine. Control group received Normal saline 10ml/kg body weight. Antidepressant activity was identified by using modified Forced Swimming Test (FST) and Tail Suspension Test (TST). Period of immobility was observed in both the models which was indicative of anti depressant activity. Standard statistical methods were used to evaluate the results. The results showed significant dose dependent antidepressant effect of EASL in Swiss albino mice for both the models in all the test groups (Test group 1, 2 and 3). EASL possess significant antidepressant activity. However, further investigations are required to determine its active constituents and molecular level of target mechanism for further use in humans.
Keywords: Antidepressant; Alangium salviifolium (L. f.) Wangerin; Forced swimming test; Tail suspension test Back to TOC