Pharmacological Study of the Glibenclamide and Glimeperide Mixed Ligands and their Zinc Complexes

Mohammad Tawkir¹*, S. A. Iqbal² and S. B. Kapoor²

¹Department of Chemistry, Arts Commerce and Science College Tukum, Chandrapur India.

²Department of Chemistry, Saifia College of Science and Education, Bhopal - 462 001 India.

Abstract:

Present Communication deals with the preliminary study fo the comparison of hypoglycemic activity of two mixed sulphonyl urea. i.e. Glibenclamide (5-chloro-N-(4- N-cyclohexyl carbonyl) sulfamoyl] phenethy] 2-methoxybenzamide (L1) adn Glimeperide (3-ethyl-4-methyl-N-(4-[N-(1r,4r)-4-methylcyclohexl carbamoyl) sulfamoyl] phenethyl)-2-oxo-2, 5-dihydro-1-H-pyrrole-1-Carboxamide (L2) in equal proportion with zinc - complex of these mixed drugs result reveals that the ternary (L1ML2) complex of these drugs with zinc gives surprising results.

Keywords:

Pharmacological study; Mixed ligands; metal complexes

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