An Efficient Synthesis, Characterization of some Novel 6 -(R) phenyl-azo-coumarin -3- carboxy(3-chloro- 4-methoxy) anilide and 2- hydroxy- 5(R)-phenyl - azo - benzylidine (3- chloro - 4 -methoxy)aniline and their Antibacterial Activity

Alok K. Pareek*, P. E. Joseph and Daya S. Seth

School of Chemical Sciences, Department of Chemistry, ST. John’s College, Agra - 282 002 India.

Abstract:

An efficient synthesis of various substituted azo-coumarin & azo-Schiff base has been synthesized by the condensation of 3-chloro-4-methoxy phenyl malon anilic acid (1a) and different substituted phenyl benzene-azo-salicylaldehyde (5a-5l) with few drops of pyridine as a condensing agent. The constitution of the newly synthesized products has been established on the basis of their spectral studies viz: IR, 1H NMR, Elemental analysis and physical properties as m.p, colour, yield%, molecular formula etc. and their antibacterial activity was carried out against S.aureus and E.coli micro-organisum.

Keywords:

Subs. Azo - Coumarins; Azo - Schiff’s Bases; Pyridine; Condensation; Malonic Acid

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