Upregulation of Rarb, Rarg, and Rorc Genes in Clear Cell Renal Cell Carcinoma

Anna Viktorovna Kudryavtseva^1,2,*, Kirill Mikhailovich Nyushko², Andrew Rostislavovich Zaretsky^3,4, Dmitriy Alekseevich Shagin³, Andrey Dmitrievitch Kaprin², Boris Yakovlevich Alekseev² and Anastasiya Vladimirovna Snezhkina¹

¹Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

²National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.

³Pirogov Russian National Research Medical University, Moscow, Russia.

⁴Evrogen Lab LLC, Moscow, Russia.

Abstract: Clear cell renal cell carcinoma (ccRCC) is one of the most frequent urological malignancies with a high mortality rate. The search for genes that could be potential targets for therapy as well as diagnostic and prognostic markers is an important task. In this work the expression of nine genes, encoding nuclear retinoid receptors, in ccRCC was analyzed by bioinformatics and quantitative PCR methods. We have identified the upregulation of RARB, RARG, and RORC genes that encode RAR-beta, RAR-gamma, and ROR-gamma nuclear retinoid receptors, correspondingly. As is well known, all of them can bind trans-retinoic acid. It allows assuming that the nuclear retinoid receptors may play significant role in the alterations of retinoic acid metabolism in ccRCC and contribute to the diseases progression

Keywords: clear cell renal cell carcinoma; nuclear retinoid receptors; gene expression; quantitative PCR

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