Virulence Factors Profile and Antimicrobial Resistance of Acinetobacter baumannii Strains Isolated from Various Infections Recovered from Immunosuppressive Patients
Mohammad DarvishiInfectious Diseases and Tropical Medicine Research Center (IDTMRC), AJA University of Medical Sciences, Tehran, Iran.
Corresponding Author Email : mohammaddarvishi@gmail.com
Abstract: Natural inherent of Acinetobacter baumanni to survive in hard conditions in surfaces and its ability to resist against commonly used antibiotics in hospitals caused it to be one of the most prevalent cause of hospital infections. The present study was carried out to research the prevalence, antibiotic resistance pattern and distribution of virulence genes in the A. baumannii strains of various infections of immunosuppressive patients. One-hundred and fifty samples were collected and cultured. Their positive results were subjected to disk diffusion and PCR. Of all 150 samples studied, 20 samples (13.33%) were infected with A. baumannii. Wound infections had the highest prevalence of A. baumannii (16%). Csga (70%) and cnf1 (50%) were the most commonly detected virulence genes. A. baumannii strains showed the highest levels of resistance against ampicillin (100%), tetracycline (95%), gentamycin (75%) and cephalexin (60%), while lowest against imipenem (5%) and ceftriaxone (35%). Statistically significant difference was seen between the type of samples and prevalence of A. baumannii, prevalence of antibiotic resistance and also distribution of virulence genes (P < 0.05). Quick determination of infections caused by A. baumanni and its treatment with imipenem can decrease the risk of A. baumanni’s infections.
Keywords: Acinetobacter baumanni;Virulence genes;Antibiotic resistance pattern;Immunosuppressive patients;Clinical infections Back to TOC