Genetic Variants in Diabetes Mellitus Patients by Amplifying the Intron of eNOS Gene in the Population of Andhra Pradesh, India
Rajasekhar Pinnamaneni and Sankar Jagarlamudi
Centre for Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar - 522 510 India.
Abstract:
Genetic variants of the endothelial nitric oxide synthase (eNOS) gene for 27bp-VNTR have been examined for their association with type 2 diabetes (T2DM)-related traits in various populations of Andhra Pradesh, India. The carriers of the rare allele (27bp-VNTR-4a) were found to have decreased HDL-C and increased DBP levels. Genetic polymorphisms examined at the eNOS locus, 27bp-VNTR appears to be a minor contributor to the variation in T2DM-related traits in populations of Andhra Pradesh, India.
Keywords:eNOS gene; genetic polymorphisms; type 2 diabetes
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