Formulation and Evaluation of an Antacid and Anti-Ulcer Suspension Containing Herbal Drugs
G. Roopa1*, R. Sudeendra Bhat2 and Murthy Sudarshan Dakshina21Sarada Vilas College of Pharmacy, Mysore India.
2J. S. S. College of Pharmacy, Mysore India.
Abstract: Herbal drugs like Glycyrrhiza glabra, Terminalia chebula, Terminalia belerica, Emblica officinalis and mineral Turbinella rapa possess anti-phlogistic, astringent and acid neutralization activity that is desirable for the treatment of gastric ulcer. The extracts of the herbs were obtained by cold maceration process and their extracts were formulated into a suspension with the varied concentration of Xanthan gum. The suspensions were then evaluated for the pH, Viscosity, sedimentation volume, redispersibility, antacid and antiulcer activity. All the formulations showed a pH in the basic range about 8.2, acid neutralizing capacity between 2-3mEq/ml, high sedimentation volume and good redispersibility .The formulation containing extracts of the herbs showed significant decrease in the ulcer index as compared to one containing the powders of these drugs .
Keywords: Glycyrrhiza glabra; Turbinella rapa; Antiulcer activity; Antacid activity Back to TOC