Saki N, Asadizadeh S, Konari A, Nikakhlagh S. Investigating the Association of PTPN22 Gene Polymorphism R620W with Scleroderma in Southwestern Iran in Khuzestan. Biomed Pharmacol J 2015;8(2)

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Nader Saki¹, Sepideh Asadizadeh², Amin Konari² and Soheila Nikakhlagh^1*

¹Associate Professor or otolaryngology, Hearing & Speech Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ²Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

DOI : https://dx.doi.org/10.13005/bpj/869

Abstract

Cleft palate imposes numerous psychological, physical, and developmental effects on patients and their families. This study attempted to evaluate the outcomes of reconstructive surgery for closing cleft palate in patients admitted to Imam Khomeini Hospital and Apadana Hospital during 2004-2010. This was a retrospective study on 275 children undergoing reconstructive surgery for cleft palate at Imam Khomeini Hospital and Apadana Hospital during 2004-2010. The demographic data included age, sex, type of cleft palate, type of surgery and its complications referring to patient’s profile. Most patients with cleft palate ranged from 1 to 3 years of age (86.9%). Most patients were young females diagnosed with hard and soft, unilateral submucosal cleft palate, whereas most cases diagnosed with bilateral cleft palate were young males. Most cases of anterior fistulas were found in patients with bilateral cleft palate, while most cases of defect were observed in soft palate and hard and soft cleft palate. The risk of postoperative complications tended to be higher in cases of bilateral cleft palate where soft and hard palates were involved at the same time.

Keywords

Reconstructive surgery; Cleft palate patients; Bilateral cleft