Microbial Index and TNF-α, IL-4, CCL17 Level Among Burn Wound Infections in Hilla City, Iraq.
Lubna Abdulazeem1, Hussein O. M. Al-Dahmoshi2* and Jwan Ahmed Ali31University of Babylon, DNA research center, Iraq.
2University of Babylon, College of Science-Biology Dept., Iraq.
3University of Babylon, College of Medicine-Anatomy Dept., Iraq.
Corresponding Author E-mail: dr.dahmoshi@yahoo.com
Abstract: Burn wound infections is the one of the most common nosocomial infections and it is mainly due to bacterial infection. A total of 30 blood and burn swab samples were taken from patients with burn attending Al-Hilla, General Teaching Hospital, in Babylon, Iraq. Twenty blood samples were taken from healthy individual as a control. Conventional bacterial culture were performed to recover bacteria and measurement of TNF-α, IL-4 and CCL17 were performed by ELISA. The results revealed that Pseudomomas aeruginosa were the common agent and compile (76.66%) followed by Escherichia coli and Klebsiella pneumoniae (6.66%) for each and (3.33%) for each of Staphylococcus aureus, Streptococcus pyogenes and Acinetobacter baumannii. Concern the serum levels of TNF-α, IL-4 and CCL17, the results revealed significant decreases of TNF-α level (51.00±16.98 pg/ml) for burn patients in comparison with healthy control (150.70±34.60 pg/ml) p˂ 0.005. For IL-4 and CCL17 the results displayed non-significant differences between burn patients and healthy control. This study conclude that the Pseudomonas aeruginosa still the main pathogen among burn wound infections and the levels of some cytokines depend upon time of collection and may revealed the worseness degree of burns
Keywords: Pseudomonas aeruginosa; TNF-α; IL-4; CCL17; Burn; Infections Back to TOC