Evaluation of Antidiabetic and Hypolipidemic Effect of Cucumis Sativus Fruit in Streptozotocin-Induced-Diabetic Rats
T. Karthiyayini¹*, Rajesh Kumar¹, K. L. Senthil Kumar¹, Ram Kumar Sahu ² and Amit Roy³¹Department of Pharmacognosy, Padmavathi College of Pharmacy, Dharmapuri India.
²Department of Pharmacognosy, Oriental College of Pharmacy, Bhopal India.
³Columbia College of Pharmacy, Mandhar, Raipur India.
Corresponding Author E-mail:singh.chandasingh2009@gmail.com
Abstract: In order to evaluate the antidiabetic activity of powder fruit of Cucumis sativus. The different doses of ethanol extract were screened for their effects on serum glucose levels in streptozotocin-induced rats and lipid profile (biochemical parameters) in blood were also observed with histopathological studies. The oral administration of 200 and 400 mg/kg body weight of ethanol extracts of powder fruit of Cucumis sativus exhibited significant antidiabetic effects in streptozotocin induced rats as compared to standard drug. In the same study the action of the extracts on diabetes induced hyperlipidemia was analyzed where the extracts significantly lowered the elevated cholesterol as well as LDL level. The drug has the potential to act as antidiabetic as well as antihyperlipidemic. The study revels that ethanol extract at dose of 400 mg/kg body weight exhibited more significant antidiabetic activity.
Keywords: Antidiabetic; Lipid profile; Cucumis sativus; Strepozotocin; Glibenclamide Back to TOC