Formulation Development and Evaluation of Diltiazem Hydrochloride Oral Disintegrating Tablets
V. Ravichandiran1, K. Masilamani2, B. Senthilnathan2, S. Hariprasad1 and D. Joseprakash21Vels college of Pharmacy, Pallavaram, Chennai India.
2Department of Pharmaceutics, Vels college of Pharmacy India.
Corresponding Author E-mail:sen03mpharm@gmail.com
Abstract: The aim of the present study was to prepare and characterize mouth dissolving tablet of Diltiazem hydrochloride (taste masked) using super disintegrants like (sodium starch glycolate and crosspovidone)and developing a suitable dosage form, exhibiting a maximum disintegration in the mouth in order to provide good or dispersible formulation. The result of Optimization of drug resin cross linking is done with parameters 1:4 as drug resin concentration ratio, stirring time 6hrs which showed 96.06% drug loading on to resin. Direct Compression method was selected to make the formulation. The granules so obtained were having good flow properties and tablets had shown satisfactory results with respect to physical parameters like hardness and friability, weight variation and disintegration. Disintegration results shown that the tablets containing SSG had much more effect on disintegration with respect to concentration, where as CP also shown good disintegration ability within the time limit but lesser effect compared to SSG. Dissolution results showed that tablet with good disintegration showed much better release than the other formulation used for the same purpose. Whereas with the same weight gain as that of high resin: drug concentration cross linked tablets showed the release 99.98% in 0.1NHCL.Among mouth dissolving formulation F6, was suited formulations having best drug release in 0.1NHCL. The results obtained were shown almost above 80% of drug release in 30 minutes. As per dissolution profile F6 was concluded as best formulation.
Keywords: Diltiazem hydrochloride; Granulation Process; Direct compression process Back to TOC