Lipid Peroxidation and Antioxidant Enzymes Status in Pre and Postmenopausal Breast Cancer
Vikas Shrivastava*1, Gunjan Shrivastava2, Manoj Pathak2 and Meenu Rai31Cancer Hospital and Research Institute (CHRI), Gwalior India.
2IASCA, ITM-Universe, Gwalior India.
3Boston College of professional studies, Gwalior India.
Corresponding Author E-mail:vikasshrivastava2@rediffmail.com
Abstract: The study was undertaken to asses the Lipid peroxidation and antioxidant enzymes status in pre and post-menopausal breast cancer subjects. Three hundred fifty female human subjects (168 normal healthy & 182 breast cancer subjects) aged between 25 -65 yrs. were selected for the study which were obtained from cancer hospital & research Institute (CHRI), Gwalior. All subjects were divided into four groups; group I (n=84) included premenopausal normal, group II (n=84) contained postmenopausal normal subjects, group III (n=91) included premenopausal breast cancer subjects and group IV (n=91) contained postmenopausal breast cancer subjects. The biochemical investigations e.g. GSH, lipid peroxidation, SOD, catalase & GPx were investigated in all group of subjects. The GSH showed significant reduction (p<0.05) in group III & IV as compared to groups I & II respectively. The lipid peroxidation, SOD, catalase and GPx showed significant elevation (p<0.05) in group III & IV as compared to group I & II respectively. The results of our study have shown higher oxygen free radical production & increased activities of antioxidant enzymes which may be a compensatory regulation of increased oxidative stress. Hence, the co-administration of antioxidants in the initial stages of the disease may be useful to the clinicians to manage the disease.
Keywords: Breast cancer; premenopausal; postmenopausal; lipid peroxidation; antioxidants; Oxidative stress Back to TOC