Controlled Oral Drug Delivery of Hypoglycemic Agent Through Particulate System
Pradeep Tyagi¹* and Pankaj Sharma²¹Department of Pharmaceutics, Bhupal Noble’s College of Pharmacy, Udaipur. Rajasthan India.
²Raj Kumar Goel Institute of Technology, 5 Th Mile Stone, Delhi-meerut Road, Ghaziabad India.
Abstract: Gastro retentive systems can be retained in the stomach for a long time so Glipizide hypoglycemic agent used as in gastro retentive formulations in the form of pellets can be developed by using extrusion-spheronization method. Pellets were found to be satisfactory in terms of floatability and drug release behavior. Floatation was achieved during the entire study period of different formulations. The surface morphology of the optimized formulation shows the pellets were smooth and spherical shape. The best formulation was considered to be the optimized one. Improve floating time, sustained drug delivery was observed when the polymer HPMC, HPC, MCC used in the ratio of 28%, 11%, 11%, respectively.
Keywords: Glipizide; Extrusion-Spheronization; Pellets; Polymers HPMC; HPC; MCC Back to TOC