Signaling Pathways of Melatonin in Prevention of Liver Disorders via Suppressing of Oxidative Stress in Cellular Level
Mohsen Mohammadi1, Mohammad Jafar Rezaie2, Ayoob Rostamzadeh3, Azra Allahveisi2, Hamid Reza Mohammadi4, Fatemeh Mohammadi5 and Ardeshir Moayeri6*
1Hepatitis Research Centerand Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
2Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
3Department of Anatomy and Neuroscience, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
4Department of Toxicology and Pharmacology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
5Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
6Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
*Corresponding Author E-mail: moayeri46@medilam.ac.ir
Abstract: Melatonin (MT) (N-acetyl-5-methoxytryptamine) is a lipophilic and hydrophilic indoleamine with various physiologic functions MT presents in all cells and tissues and distributes in all cell compartments. Liver is the only organ of circulating MT metabolism. The roles of MT in various liver pathologies have been extensively studied, and it is believed that oxidative stress (OS) and lipid peroxidation (LPO) are the key causing factors of almost all conditions compromising liver function, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), diabetes, liver fibrosis and cirrhosis. MT improves energy production and reduces apoptosis OS and LPO in liver. MT protects liver against OS through multiple ways: inhibition of inflammatory cytokines, direct scavenge of free radicals, stimulation of antioxidant enzymes, decrease of mitochondrial electron leakage and synergistic function with other classical antioxidants.
Keywords: Liver disease; Melatonin; Free radical; Reactive oxygen species Back to TOC