Maternal Dietary Micronutrient Restriction During Preconception, Conception and Postnatal Life Predispose the Offspring to Insulin Resistance and Hypertension in Adult Life
M. S. Mohamed Jaabir¹*, JF. Rosario², S. Senthil kumar¹ and P. Geraldine³

1Department of Biotechnology, Jamal Mohamed College (Autonomous), Tiruchirappalli - 620 020 Idnia.

²Department of Obstetrics and Gynecology, University of Texas, Health Science Center, San Antonio, Texas-78229-3900 Mexico.

³Department of Animal Science, Bharathidasan University, Tiruchirappalli - 620 024 India.

Abstract: To assess the effect of maternal dietary micronutrient restriction during preconception, conception and postnatal days on insulin resistance, fat metabolism and systolic blood pressure in offspring. Female weanling mice received a control or a 50% micronutrient restricted (MR) diet and mated with control males. Pups born to the dams on the restricted diet were weaned on to the restricted diet till postnatal day (PD) 360. At birth, pups from deficient dams had reduced birth weight and crown rump length. Increased fasting glucose, insulin, total cholesterol and triglycerides levels were observed in the offspring of MR group. At PD-120, MR restricted offspring had an elevated systolic blood pressure than controls. Compared with controls, total body electrical conductivity measurements indicated significantly higher body fat percentage, lower lean body mass and fat-free mass in MR offspring besides elevated plasma triacylglycerols. Maternal micronutrition restriction per se resulted in an increased body fat and in plasma triglycerides, free fatty acids and total cholesterol concentrations in the offspring. These changes seem to predispose the offspring to insulin resistance and hypertension in later life.

Keywords: Micronutrient restriction; Insulin Resistance; Hypertension; TOBEC

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