Neuroprotective Effect of Hydroalcoholic Seed Extract of Langenaria Siceraria (Mol) Standl. On Hypoxia Neurotoxicity Induced in Wistar Rats
Maid Priyanka Prakash*,P. Vengal Rao , R. V. Venkataramanan , V. Chitra and M. SumithraDepartment of Pharmacology, SRM College of Pharmacy, SRM University, Kattankulathur, India.
Abstract: Oxidative stress is implicated as one of the primary factor that contributes to the neurodegerative disease, brain damage, stroke, hypoxia etc. The aim and objective of the present study is to investigate the neuroprotective effect of hydrolcoholic seed extract of Langenaria siceraria on hypoxic neurotoxicity induced in wistar rats. The animals were divided into five groups of 8 animals each. Hypoxic neuronal damage was induced by the administration of sodium nitrite 30mg/kg p.o for 14 days. The hydroalcoholic extract (HAE) of L. siceraria was administered at doses 200mg/kg, 400mg/kg b.w, p.o for 14 days. Alteplase 0.9mg/kg i.v was used as standard. Alteration in neurological behavior (Beam walking, Cylinder test, Adhesion test) was performed; changes in various biochemical and antioxidant levels were estimated. The drug treated group showed normal neurological behavior comparable with that of normal control group. The level of Glutathione, Dopamine was reduced and level of TBAR's and nitrates was increased in disease control. The drug treated groups showed elevated levels of Glutathione, Dopamine, and reduced levels of TBAR's and Nitrates in dose dependent manner.
Keywords: Langenaria Siceraria; Oxidative stress; Neurological behavior; Hypoxia; Neurotoxicity Back to TOC