Synthesis and Pharmacological Study of Some Mannich Bases of Benzimidazolyl Quinazolinones Against Tribolium Confusum
Pramilla Sah* and Vanita Kachhawaha

Department of Chemistry, J.N.V. University, Jodhpur - 342 005 India.

Abstract: The Mannich bases 2–phenyl–3–(1’H–morpholino/piperidino/ diphenylamino–methyl–2’–alkyl benzimidazolo–6/6,8–disubstituted quinazolin–4(3H)–ones were synthesized by treating 2–phenyl–2’–methyl/ethyl benzimidazolo–6/6,8–disubstituted quinazolin–4(3H)–ones with formaldehyde and appropriate secondary amines. The synthesized compounds were then evaluated for their insecticidal activity against Tribolium confusum, the host being jawar seeds. The survival percentage of the beetle reduced significantly and the development period of the insect was also prolonged between 10–14 days on an average by using 1.0, 2.5 and 5.0 ml/100 gm of the host seed by these Mannich bases.

Keywords: Mannich bases; Tribolium confusum; benzimidazolyl quinazolinones

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