Comparison of Protective Effects of Omega3 Fish Oil and Aqueous Extract of Glycyrrhiza glabra Root on Thioacetamide Induced Lipid Toxicity in Male Rats.
D. Moghadamnia1,2*, M. Mokthari3 and S. Khatamsaz31Department of Biology , Fars Science and Research Branch,Islamic Azad University ,Fars ,Iran. 2Department of Biology,Shiraz Branch,Islamic Azad University, Shiraz,Iran. 3Department of Biology,Kazerun Branch,Islamic Azad University, kazerun,Iran.
Abstract: Thioacetamide(TAA) is an organic compound and is a potentotoxin.TAA has dyslipidemic effects because of its rapid elimination and cumulative injury when it is given intermittently,presumably by free radical-mediated lipid.Glycyrrhiza glabra is a well-know medical plant.Glycyrrhiza glabra root reduce the risk of coronary heart disease.Omga3 fatty acids are widely used to treatment hypertriglyceridema.Omega3 fatty acid are know to act as hypolipidaemics.The current investigation was designed to explore the possible protective effects of omega3 fish oil and glycyrrhiza glabra aqueous extract on TAA-induced dyslipidemia in male rats.63 wistar male rats were divided into 9 group. Control group.Sham group1.each rat of the group received 0.4ml olive oil as a solvent omega3 fish oil supplements orally per day for 3 months. Sham group2.each rat of the group received 150 mg/kg of TAA intrapertionealy in a single dose for 3months. Experimental group 1,2,3. each rat of the 100,200,300 mg/kg of omega3 fish oil supplements orally per day for 3 months and 150 mg/kg of TAA intrapertionealy in a single dose for 3months .Experimental group 4,5,6.each rat of the group received 100,200,300 mg/kg of aqueous extract of glycyrrhiza glabra root orally per day for 3 months and 150 mg/kg of TAA intrapertionealy in a single dose for 3months and 150 mg/kg of TAA intrapertionealy in a single dose for 3months. The provided blood samples were tested for total cholesterol,HDL,LDLcholesterol,triglyceride and FBS serum levels.pretreatment with 100,300mg/kg of aqueous extract of glycyrrhiza glabra or by 300mg/kg omega3 fish oil supplements significantly reduced thioacetamide-induced elevation in plasma levels of total cholesterol. Pretreatmen with the omega3 fish oil andaqueous extract of glycyrrhiza glabra rootat alldosesshowed nosignificant difference inserum levels oftriglyceride,LDL,HDL cholesterol and FBS comparing with thioacetamide group(P<0.05).In conclusions,The study suggests that thioacetamide-induced lipid toxicity in male rats can be ameliorated by oral administration of aqueous extract of glycyrrhiza glabra root and omega3 fish oil.
Keywords: Glycyrrhizaglabra; Omega3 fish oil; Thioacetamide; Dyslipidemia Back to TOC