HbA1c Measurement: Comparison of Results of Five Commonly Used Kits in Iran
Reza Mohammadi1,2 and Vagihe Norozi11Department of Biochemistry and Pharmacology, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran. 2Department of Biochemistry of External Quality Assessment Program, Iranian Association of Clinical Laboratory Doctors, Tehran, Iran.
Abstract: Results of HbA1c measuring is used in management diabetic patients. So agreement between results of different HbA1c measuring methods and kits is critical in medical decision making.Results of measring HbA1c of 55 patient’s blood samples with five commonly used kits in Iran, including Pars Azmon, Pishtaz Teb, Biosystem, Roche, and NycoCard, compared with total mean results. All kit results showed good correlation (r>0.96) with total mean results. In paired t-test analysis, results of Pars Azmon, Biosystem, and NycoCard had no statistically significant difference with total mean results, but results of Pishtaz Teb and Roche kits were significantly lower and higher than total mean results, respectively. However, this differences were clinically insignificant.With respect to results of external quality assessment program (EQAP) in Iran and results of this study, analytical performance of studied kits are acceptable, except for Roche kit which had a positive bias.
Keywords: Glycated hemoglobin; HbA1c; diabetes mellitus Back to TOC