Diuretic Activity of Ethanolic Extract of Pistia Stratiotes in Rats
R. K. Sahu ¹*, A. Roy¹, A. K. Jha² and U. Sharma³¹Department of Pharmacognosy, Oriental College of Pharmacy, Bhopal India.
²Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai, Durg India.
³Institute of Pharmacy, Jalpaiguri India.
Corresponding Author E-mail: ramsahu79@yahoo.co.in
Abstract: Kidney, the excretory organ of our body serves the important function of excretion of waste products, regulation of fluid volume and electrolyte content of the extracellular fluid. Diuretics are drugs capable of increasing levels of urine. The diuretic activity of ethanol extract of Pistia stratiotes (ETPS) leaves was studied in male wistar albino rats at 5th h and 24th h intervals. The animals were divided into 5 groups: control, urea, furosemide, 200mg/kg and 400mg/kg ethanol extract. The ethanol extract was administered intraperitoneally (i.p) and all animals were pretreated with saline before starting the experiment. The urine volume (in ml) at 5th h and 24th h duration were measured. The urine output increased significantly in urea, furosemide and both ETPS groups. Ethanol extract increased the urine volume and electrolytes balance in a dose dependent manner. The results indicate that ETPS has significant diuretic activity, which supports the traditional claim about the Pistia stratiotes being used as a diuretic.
Keywords: Pistia stratiotes; Diuretics; Furosemide; Urine volume; intraperitoneally Back to TOC