Compatibility Studies of Intrinsic lubricants for Effervescent Tablets: Formulation and In Vitro Evaluation
B. M. Dinesh¹ and R. K. Mohamed Mutahar²*1Department of Pharmaceutics. K.L.E.S. College of Pharmacy. II Block. Rajajinagar. Bangalore - 560 010 (India).
²Department of Pharmaceutics. Dr. H.L.T.College of Pharmacy, Kengal, Channapatna, Bangalore (Rural) - 571 502 (India).
Abstract: The purpose of the present research was to compare the characteristics of different lubricants like Talc, Magnesium stearate (MGS), Polyethylene glycol 8000 (PEG), and Sodium benzoate (SBZ) used in Effervescent Tablets (ETs). Another main aim of the present work was also study the dissolution or scumming problems of lubricants in formulation of ETs. The formulated powder blends were evaluated for angle of repose, bulk density, tapped density, compressibility index and hausner ratio (Table: 2) were showed satisfactory flow property.The ETs were subjected to weight variation, thickness, hardness, friability, and drug content tests were found to be within limits (Table: 3). The disintegration time of all formulations was in between 17 to 22- Sec (Table: 3) (Fig: 2) and were slightly acidic (pH 4.2 to 4.4) (Table: 3) to augment the taste of the solution.The dissolution of F4 and F10 was 98.6% and 98.4% for 03 hrs in 6.8 pH, (Fig: 1) was excellent as compared to all other formulations (Fig: 1a). The present study concluded that, the single SBZ used in Formulation F4 (Table: 1) for ETs was the best lubricant. Moreover the combination of SBZ, with MGS and PEG, Formulation F10 (Table: 1) in the ratio of 6:1:1 which enhances the plasticity and external appearance of the final ETs. The selected Formulation F10 was further subjected to infrared interpretation (Fig: 4&5) there was no interaction between lubricants and Drug, and stability studies showed they were quite stable at different RT and RH (Fig: 6).
Keywords: Effervescent Tablets; Lubricants; Scumming; Talc; Sodium benzoate; Nicotinic acid Back to TOC